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desvenlafaxine will raise the amount or result of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Caution/Keep track of. Desvenlafaxine inhibits CYP2D6; with increased desvenlafaxine doses (ie, 400 mg) minimize the CYP2D6 substrate dose by as many as 50%; no dosage adjustment required with desvenlafaxine doses seven consecutive times i